“It’s absolutely fascinating to see Darwinian principles at work here. This community of people has developed their own biologically unique response to a truly terrible epidemic. The fact that this genetic evolution has happened in a matter of decades is remarkable.”

Professor John Collinge, Director of the Medical Research Council (MRC) Prion Unit

A community in Papua New Guinea that suffered a major epidemic of a fatal brain disease called kuru has developed strong genetic resistance to the disease, according to new research by Medical Research Council scientists.

Kuru is a fatal prion disease geographically unique to an area in Papua New Guinea. In the mid 20th Century, an epidemic of kuru devastated a population in the Eastern Highlands of Papua New Guinea. The infection was passed on at funeral feasts, where mainly women and children consumed their deceased relatives as a mark of respect and mourning -a practice banned and ceased in the late 1950s.

Prion diseases or transmissible spongiform encephalopathies belong to group of fatal progressive conditions that affect the nervous system in humans and animals. In humans, prion diseases impair brain function, causing memory changes, personality changes, a decline in intellectual function (dementia), and problems with movement that worsen over time.

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